Hemodilution both ways: phenomenon and tool Narrative review

Keywords:

Anemia, hemodilution, blood viscosity, oxygen transport, fluids


Published online: Mar 18 2026

https://doi.org/10.56126/77.1.08

Himpe D.1

1 Dirk G. A. Himpe, MD, PhD, EDIC

Abstract

Hemodilution refers to the dilution of blood components. Whether it is an iatrogenic effect of volume replacement or intentional as a treatment, it also occurs as a consequence of disease. Hemodilution affects blood viscosity with a significant impact on blood rheology. The prevalence of hemodilution anemia is high and therefore a common clinical phenomenon. Hemodilution can also be considered as a tool when applied intentionally, as an opportunistic therapeutic option, as a specific treatment, or as a blood-sparing technique.